Which drugs are direct vasodilators?

January 8, 2021 Off By idswater

Which drugs are direct vasodilators?

Indications

  • Direct-acting vasodilators (hydralazine, minoxidil, nitrates, nitroprusside)
  • Calcium channel blockers (verapamil, diltiazem, nifedipine, amlodipine)
  • An antagonist of the renin-angiotensin-aldosterone system (angiotensin receptor blockers, angiotensin-converting-enzyme inhibitors)

Why are beta blockers frequently administered with direct-acting vasodilators?

pressure in hypertension by lowering vascular resistance with direct-acting vasodilators and to use beta-adrenergic blockade secondarily to prevent reflex stimulation of the heart, thus maintaining an unchanged cardiac output.

Does hydralazine work on arteries or veins?

Some drugs used to treat hypertension, such as calcium channel blockers also dilate blood vessels. But the vasodilators that work directly on the vessel walls are hydralazine and minoxidil.

What hormone causes vasodilation?

Corticotropin-releasing hormone causes vasodilation in human skin via mast cell-dependent pathways.

What is the build up of plaque in the arteries called?

Atherosclerosis is the buildup of fats, cholesterol and other substances in and on your artery walls. This buildup is called plaque. The plaque can cause your arteries to narrow, blocking blood flow.

What drugs increase blood flow?

Pentoxifylline is used to improve blood flow in patients with circulation problems to reduce aching, cramping, and tiredness in the hands and feet. It works by decreasing the thickness (viscosity) of blood. This change allows your blood to flow more easily, especially in the small blood vessels of the hands and feet.

Is histamine a vasodilator?

Histamine (HA) is a potent mediator in many physiological processes: it causes vasodilation or vasoconstriction, stimulates heart rate and contractility, and contraction of smooth muscles in the intestine and airways.

When to use a direct acting vasodilator?

Hypertension. However, it is used in treating acute hypertensive emergencies, secondary hypertension caused by preecclampsia, and pulmonary hypertension. It is often used in conjunction with a beta-blocker and diuretic to attenuate the baroreceptor -mediated reflex tachycardia and renal sodium retention, respectively.

Why do vasodilators dilate the blood vessels?

As a result, blood flows more easily through your vessels. Your heart doesn’t have to pump as hard, reducing your blood pressure. Some drugs used to treat hypertension, such as calcium channel blockers — which prevent calcium from entering blood vessel walls — also dilate blood vessels.

How are vasodilators used at the Mayo Clinic?

By Mayo Clinic Staff. Vasodilators are medications that open (dilate) blood vessels. They affect the muscles in the walls of your arteries and veins, preventing the muscles from tightening and the walls from narrowing. As a result, blood flows more easily through your vessels.

Which is the best direct acting vasodilator for tachycardia?

Hydralazine, which is highly specific for arterial vessels, reduces systemic vascular resistance and arterial pressure. Indirect cardiac stimulation (e.g., tachycardia) occurs with hydralazine administration because of activation of the baroreceptor reflex. The direct acting vasodilator that is used clinically is hydralazine.