Which of the following is most common adverse effect of amphotericin B Mcq?

July 14, 2020 Off By idswater

Which of the following is most common adverse effect of amphotericin B Mcq?

Adverse Effects The most common side effects of amphotericin B include: Loss of potassium. Loss of magnesium. Anaphylaxis.

Why does amphotericin B affect the kidneys?

Amphotericin B binds to sterols in cell membranes, thereby creating pores that compromise membrane integrity and increase membrane permeability. It binds not only to ergosterol in fungal cell walls but also to cholesterol in human cell membranes; this is what accounts for its nephrotoxicity.

Which of the following is the most common adverse effect of amphotericin B Mcq?

What is the function of polyenes?

Polyenes bind to ergosterol in the cell membrane of fungi and form aqueous pores that promote leakage of intracellular ions and disrupt active transport mechanisms dependent on membrane potential. They can be fungistatic or fungicidal.

Are polyenes fungicidal or fungistatic?

Polyenes irreversibly bind to the cell membrane sterol, ergosterol, causing disruption by increasing cell membrane permeability. They are fungistatic at low concentrations and become fungicidal at higher concentrations.

What drugs should not be taken with amphotericin?

Some products that may interact with this drug include: anti-cancer drugs (e.g., mechlorethamine, nitrogen mustard), azole antifungals (e.g., ketoconazole, itraconazole), cidofovir, digoxin, flucytosine, medications that affect the kidneys (e.g., pentamidine, tacrolimus, aminoglycosides such as gentamicin), muscle …

What is amphotericin B used to treat?

Amphotericin B is an antifungal medication that fights infections caused by fungus. Amphotericin B is used to treat serious, life-threatening fungal infections.

What are the side effects of amphotericin B polyenes?

Polyenes. Toxicity associated with amphotericin B includes infusion-related nausea, vomiting, and rigors; chronic toxicity is primarily renal [4]. This toxicity may lead to discontinuation of therapy; in response, lipid formulations were developed and are characterized by reduced toxicity [5].

What kind of antibiotic is amphotericin B?

Amphotericin B is the model polyene macrolide antibiotic and is the sole member of this class used systemically. Polyene antifungal antibiotics are large molecules, consisting of a long polyene, lipid-soluble component and a markedly hydrophilic component.

Which is the model antibiotic for polyene macrolide?

Amphotericin B is the model polyene macrolide antibiotic and is the sole member of this class used systemically. Polyene antifungal antibiotics are large molecules, consisting of a long polyene, lipid-soluble component and a markedly hydrophilic component. Amphotericin B acts as both a weak base and a weak acid, and as such is amphoteric.

Which is an example of a polyene antimycotic agent?

Chemical structure of Amphotericin B. Amphotericin B is an example of a yellow polyene antimycotic agent. Note the alternating double and single bonds in the center and the mycosamine group in the bottom-right corner.