What are the congenital abnormalities associated with CMV infection?

March 20, 2020 Off By idswater

What are the congenital abnormalities associated with CMV infection?

Some babies with signs of congenital CMV infection at birth may have long-term health problems, such as: Hearing loss. Developmental and motor delay. Vision loss.

What test is used for CMV?

The standard laboratory test for diagnosing congenital CMV infection is polymerase chain reaction (PCR) on saliva, with urine usually collected and tested for confirmation. The reason for the confirmatory test on urine is that most CMV seropositive mothers shed CMV in their breast milk.

How is CMV identified?

restriction Testing should be done on the babies’ urine, saliva (preferred), or blood using polymerase chain reac- tion (PCR) to detect CMV DNA, or viral culture to detect live virus. Congenital CMV infection cannot be diagnosed with antibody testing (IgG, IgM). Treat babies who have signs of congenital CMV at birth.

What are CMV results?

A positive CMV DNA test may mean CMV is present and you have, or the newborn tested, has an active infection. High levels of viral DNA may indicate a more severe infection with serious symptoms.

Is congenital CMV curable?

CMV spreads from person to person through body fluids, such as blood, saliva, urine, semen and breast milk. There is no cure, but there are medications that can help treat the symptoms.

Does cytomegalovirus cause brain damage?

CMV Encephalitis: CMV can cause damage to the brain. If it reaches the brain and the immune system cannot control it, death can occur within weeks to months. If brain damage is less severe, dementia, confusion, fever and memory problems can occur.

What are the long term effects of cytomegalovirus?

CMV is the most common congenital infection in the U.S. Most infants will have no permanent health consequences, but a small number will have at birth or will develop long-term neurological conditions, such as hearing loss, visual impairment, seizures, or disabilities f mental or physical function.

How is valganciclovir used to treat congenital CMV?

Treating symptomatic congenital CMV disease with valganciclovir for 6 months, as compared with 6 weeks, did not improve hearing in the short term but appeared to improve hearing and developmental outcomes modestly in the longer term. (Funded by the National Institute of Allergy and Infectious Diseases; ClinicalTrials.gov number, NCT00466817

How is ganciclovir used to treat congenital cytomegalovirus?

Case 21-2021: A 33-Year-Old Pregnant Woman with Fever, Abdominal Pain, and Heada… List of authors. Ravit Arav-Boger, M.D., The treatment of symptomatic congenital cytomegalovirus (CMV) disease with intravenous ganciclovir for 6 weeks has been shown to improve audiologic outcomes at 6 months, but the benefits wane over time.

When to use CMV seroconversion in a patient?

In D+/R- patients, CMV serology testing is for the most part not clinically useful for predicting subsequent disease. However, seroconversion by 6 months may be useful for identifying patients at risk of late-onset CMV disease.

What are the secondary end points of valganciclovir?

Secondary end points included the change in hearing from baseline to follow-up at 12 and 24 months and neurodevelopmental outcomes, with each end point adjusted for central nervous system involvement at baseline. A total of 96 neonates underwent randomization, of whom 86 had follow-up data at 6 months that could be evaluated.