Why does pertussis cause lymphocytosis?

July 26, 2019 Off By idswater

Why does pertussis cause lymphocytosis?

Pertussis toxin (PT), from Bordetella pertussis, causes lymphocytosis and increased IL-4 and IgE secretion. The lymphocytosis is associated with impaired entry of lymphocytes into lymph nodes. The dose response of PT on IL-4 secretion was found to be similar to those for lymphocytosis and IgE production.

Does pertussis cause leukocytosis?

Pertussis leukocytosis is caused by pertussis toxin, a soluble protein toxin released by Bordetella pertussis during infection, but the exact mechanisms by which this occurs are still unclear.

What is the signs and symptoms of pertussis?

After 1 to 2 weeks and as the disease progresses, the traditional symptoms of pertussis may appear and include:

  • Paroxysms (fits) of many, rapid coughs followed by a high-pitched “whoop” sound.
  • Vomiting (throwing up) during or after coughing fits.
  • Exhaustion (very tired) after coughing fits.

How do you rule out pertussis?

Clinicians commonly use several types of laboratory tests to diagnose Bordetella pertussis. Scientists consider culture the gold standard because it is the only 100% specific method for identification. Other tests that can be performed include polymerase chain reaction (PCR) and serology.

What is absolute lymphocytosis?

Absolute lymphocytosis is the condition where there is an increase in the lymphocyte count beyond the normal range while relative lymphocytosis refers to the condition where the proportion of lymphocytes relative to white blood cell count is above the normal range.

What happens Increase Lymphocytes?

High lymphocyte blood levels indicate your body is dealing with an infection or other inflammatory condition. Most often, a temporarily high lymphocyte count is a normal effect of your body’s immune system working. Sometimes, lymphocyte levels are elevated because of a serious condition, like leukemia.

Will pertussis go away?

Antibiotics lessen the symptoms if given during the early stages of illness. When antibiotics are started later in the illness, the damage from pertussis is already done and the cough will last until the lungs heal. Pertussis bacteria die off naturally after three weeks of coughing.